Merek dagang untuk preparat kombinasi campuran dari metildopa dan hidroklorotiazid.
|Trade names||Aldomet, Aldoril, Dopamet, others|
|by mouth, IV|
|ATC code||C02AB01 (WHO)
C02AB02 (WHO) (racemic)
|Onset of action||4 to 6 hrs|
|Biological half-life||105 minutes|
|Duration of action||10 to 48 hrs|
|Excretion||Kidney for metabolites|
|Chemical and physical data|
|Molar mass||211.215 g/mol|
|3D model (Jmol)||Interactive image|
|(what is this?)|
Methyldopa, sold under the brand name Aldomet among others, is a medication used for high blood pressure. It is one of the prefered treatments for high blood pressure in pregnancy. For other types of high blood pressure including very high blood pressure resulting in symptoms other medications are typically prefered. It can be given by mouth or injection into a vein. Onset of effects is around 5 hours and they last about a day.
Common side effects include sleepiness. More severe side effects include red blood cell breakdown, liver problems, and allergic reactions. Methyldopa is in the alpha-2 adrenergic receptor agonist family of medication. It works by stimulating the brain to decrease the activity of the sympathetic nervous system.
Methydopa was discovered in 1960. It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system. The wholesale cost in the developing world is about 4.31 to 9.48 USD per month. In the United States it costs less than 25 USD per month.