Merek dagang untuk preparat kombinasi campuran dari metildopa dan hidroklorotiazid.
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|Trade names||Aldomet, Aldoril, Dopamet, others|
|ATC code||C02AB01 (WHO)
C02AB02 (WHO) (racemic)
|Biological half-life||105 minutes|
|Excretion||Renal for metabolites|
Systematic (IUPAC) name: (S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid
|Chemical and physical data|
|Molar mass||211.215 g/mol|
|3D model (Jmol)||Interactive image|
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|Wikimedia Commons has media related to Methyldopa.|
Methyldopa, sold under the brand name Aldomet among others, is a centrally acting antihypertensive agent. Its is no longer frequently used following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension.
It is metabolized to alpha-methylnorepinephrine in the brain, and this compound is thought to activate central alpha-2 adrenergic receptors (Gerber, 1990). Being a selective agonist for α2 adrenergic receptors, psychoactive drug is used as a sympatholytic or antihypertensive.
Methydopa was discovered in 1960. It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.