Merek dagang untuk preparat spironolakton.
|Pronunciation||spy-ROW-no-LAK-tone or speer-OH-no-LAK-tone|
|Trade names||Aldactone, Spiractin, Verospiron, many others; combinations: Aldactazide (+HCTZ), Aldactide (+HFMZ), Aldactazine (+altizide), others|
|ATC code||C03DA01 (WHO)|
|Protein binding||Spironolactone: 88% (to albumin and AGP equivalently)
Canrenone: 99.2% (to albumin)
|Metabolism||Liver (deacetylation, dethiolation, and thiomethylation)|
|Metabolites||7α-TMS, 6β-OH-7α-TMS, canrenone, others
(All three active)
|Biological half-life||Spironolactone: 1.4 hours
7α-TMS: 13.8 hours
6β-OH-7α-TMS: 15.0 hours
Canrenone: 16.5 hours
Systematic (IUPAC) name: S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-Dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
|Synonyms||SC-9420; 7α-Acetylthio-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone|
|Chemical and physical data|
|Molar mass||416.574 g/mol|
|3D model (Jmol)||Interactive image|
Spironolactone, marketed under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that do not improve with supplementation, early-onset puberty, and acne and excessive hair growth in women. It is also a part of hormone therapy in transgender women. Spironolactone is taken by mouth.
Common side effects include electrolyte abnormalities particularly high blood potassium, nausea, vomiting, headache, rashes, and a decreased desire for sex. In those with liver or kidney problems, extra care should be taken. Spironolactone has not been well studied in pregnancy and should not be used to treat high blood pressure of pregnancy. It is a steroid that blocks the effects of aldosterone and testosterone and has progesterone-like effects. Spironolactone belongs to a class of medications known as potassium-sparing diuretics.
Spironolactone was introduced in 1959. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale cost in the developing world as of 2014 is between 0.02 and 0.12 USD per day. In the United States it costs about 0.50 USD per day.